![tf2 blood in the water tf2 blood in the water](https://64.media.tumblr.com/523a0c6ab426d484e68a3cb46f92809a/tumblr_inline_p9is5cKUOn1rp17fa_250.png)
We compare their capability of detecting GFAP in a clean-buffer and serum-matrix by using gold-coated quartz-crystal-microbalance (QCM) sensors.
![tf2 blood in the water tf2 blood in the water](https://64.media.tumblr.com/5620d895dcee263ff6f15d6821f5e07a/tumblr_inline_p9is5arUkT1rp17fa_250.png)
Here, we develop three different detection strategies for GFAP, among the most popular in the biosensing field and never examined side by side within the experimental frame. These pathologies are glioblastoma multiforme (GBM), traumatic brain injuries (TBIs), multiple sclerosis (MS), intracerebral hemorrhage (ICH), and neuromyelitis optica (NMO). The pathologies which can be linked to the presence of GFAP in blood severely affect the human central nervous system.
![tf2 blood in the water tf2 blood in the water](https://images.gamebanana.com/img/ss/mods/58843dfe2d8ab.jpg)
Glial-fibrillary-acidic-protein (GFAP) has recently drawn significant attention from the clinical environment as a promising biomarker. Nonetheless, the higher sensitivity and dynamic range obtained with respect to a representative 100 MHz L-SAW sensor as long as the real-time measurements of the BSA adsorption (with an estimated limit of detection of 90 ng/mm2) show that UHF Love SAW sensors have the potential to be used for bio-sensing applications, such as point of care diagnostics.
TF2 BLOOD IN THE WATER PORTABLE
The all-electrical readout system as long as the small dimensions make the presented device particularly promising for portable UHF sensing platforms. Then, we measured the adsorption kinetics of three different concentrations of bovine serum albumin (BSA) in water on the sensor surface, demonstrating biomolecule detection. Measurements of phase and amplitude (related to change of density and viscosity, respectively) show higher sensitivity and dynamic range than a representative 100 MHz L-SAW sensor. The sensor performance was first tested with mixtures of different volume percentages of isopropyl alcohol (IPA) in water. Here, we present a multiplexable, highly miniaturized UHF L-SAW device for real-time sensing applications. Indeed, the ultra-high frequency (UHF) range has not been explored yet for L-SAW sensing devices because it requires non-trivial fabrication and measurement setup. It is possible to enhance both these parameters by increasing the working frequency of these devices, but this is still a challenge. High miniaturization and sensitivity are desirable in particular for point of care diagnostics or on-site measurements. Love surface acoustic wave (L-SAW) devices are ideal for real-time sensing applications.